NeuroPointDX presented a poster at the International Society for Autism Research (INSAR) 2021 Virtual Meeting Annual Meeting (May 3-7, 2021).
OVERVIEW
Goals:
• Identify alterations in metabolism helpful to stratify CAMP ASD subjects into subpopulations of similar metabolic phenotypes (i.emetabotypes)
• Develop a quantitative screening approach based on measurement of plasma metabolites to identify children at risk of ASD and inform on more precise intervention
Methods:
• CLIA/CAP certified quantitative LC-MS/MS measurement of 42 plasma metabolites
• Computation to develop test of metabolic dysregulation associated with risk of ASD
Results:
• Metabolites and ratios of metabolites identified dysregulation associated with 8 clusters of metabotypes. Clusters represent metabotypes that identify similar dysregulation.
• A test battery based on a subset of these ratios identified ASD CAMP subjects with 63% sensitivity and 90% specificity.
